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The Best Lyme Disease Test Kit: Which One Should You Choose?

Written by Dr. Diane Mueller

There are a wide variety of Lyme Disease Test Kits available. Using a specialty lab that focuses on the development of accurate testing and results is essential for Lyme Disease Testing. There are a lot of problems with the tests that are run at standard facilities for Lyme Disease. Let’s dive in to find which ones are the best!

Lyme Disease Test Kit

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The Lowdown on Lyme Disease Test Kits

Kit Types: EIA, Western Blot, and More!

First up, we’ve got the trusty Enzyme Immuno Assay (EIA) test. It’s typically the first line of testing, checking for Lyme antibodies. But it’s not perfect – it can miss up to 30% of cases. That’s where the Western Blot test comes in, which looks to confirm any positive results.

For those tricky cases where the disease is playing hide-and-seek with your immune system, there are PCR and antigen detection tests. They’re like the Sherlock Holmes of the testing world, hunting down the bacterium’s DNA or antigens directly.

How to Use The Test Kits

Using these kits is a breeze – all you do is “prick your finger and wait.” You collect a few drops of blood, pop it in the kit, and voila! The test looks for those Lyme-fighting antibodies. 

The Best of the Best: Lyme Disease Test Kit Companies

Vibrant Wellness: The Overachiever 

Vibrant Wellness is our favorite in the pack. They offer a range of tests, from Western Blot to PCR, and they don’t just stop at Lyme. They’re checking for co-infections too, like Bartonella and Babesia. It’s like getting a full-body scan for your health.

Their 2.0 kit is like the deluxe edition, testing for all sorts of extras like Powassan, West Nile, and even the dreaded Strep. All of this can be tested with a little finger prick. No need to brave the needle at the doctor’s office.

IgeneX: The People’s Champ

IgeneX offer test kits that you can get without a doctor’s note, so you’re in control. And they’ve got options – you can give them blood or urine, depending on how recent you think you got Lyme disease. They’re on the lookout for all the usual suspects: Borrelia, Babesia, Bartonella, and the gang. It’s like having your own personal bouncer for your body.

DNA Connexions: The Urine Whisperer

DNA Connexions is a PCR related test that is done through a urine collection. Oftentimes, getting a massage or going for a walk prior to urine collection helps to elicit a positive result as these types of activities get the circulation moving and allow for Lyme DNA to end up in the blood and then the urine. This company tests for  lyme co-infections such as Borrelia recurrentis, Borrelia miyamotoi, Babesia microti, Babesia divergens, Babesia duncani, Bartonella bacilliformis, Ehrlichia chaffeensis, Bartonella henselae, Bartonella quintana, and Anaplasma phagocytophilum.

Galaxy Labs: The User-Friendly Favorite

Galaxy Labs tests for Borrelia (Lyme), Babesia, Bartonella, Ehrlichia, Anaplasma, and Rickettsia. Galaxy labs has a different testing mechanism using nanotrap technology. The purpose of this technology is to trap Lyme Antigens at higher concentration in the urine sample, thus reducing the possibilities of a false negative. They recommend using a combination of nanotrap testing with the more traditional Elisa and western blot mechanisms in order to reduce the rates of false negatives.  This particular sample is done with urine so it is easy to do from home.

Accuracy and Reliability of Lyme Disease Test Kits

You may be wondering if you can really trust a test you do at home? 

How to Spot a Winner

When you’re trying to pick a test, you gotta look at a few things. First off, what kind of test is it? Some, like PCR tests from DNA Connexions, are looking for the actual Lyme bacteria. Others, like Galaxy Labs’ nanotrap, are hunting for Lyme proteins. The protein-sniffers might be a bit more on-target.

Next up, is the company legit? Do they have a good reputation? Do they offer a comprehensive set of tests, or just certain diagnostics? And finally, is it easy to use? Even the best test is garbage if you can’t figure out how to do it. The top kits come with instructions even a monkey could follow. 

The Good, the Bad, and the Ugly: Pros and Cons of Home Testing

The Good

Let’s start with the good stuff. Home test kits are like having a lab in your pocket. No schlepping to the doctor’s office, no awkward small talk with the nurse. You’re in charge –  and the sooner you know you’ve got Lyme, the sooner you can treat it effectively.

The Bad

But it’s not all sunshine and rainbows. Accuracy can be a bit of a crapshoot with home tests. Even the big names like Vibrant Wellness and IgeneX can have some hiccups.

They can give false positives where it says you’ve got Lyme when you really don’t. False negatives are even worse – leaving Lyme sneaking around undetected.

And let’s be real, some of us are better at following directions than others. One wrong move and you could botch the whole test.

So, it’s a bit of a balancing act. You’ve got the convenience and speed of home tests on one hand, and the chance of wonky results on the other. It’s up to you to decide which way to tip the scales.

Choosing the Right Lyme Kit for You

What to Look For

When you’re ready to take the plunge and buy a Lyme test kit, there are a few things to keep in mind.

  • First and foremost, accuracy is key. You don’t want a kit that’s about reliable. Vibrant Wellness, IgeneX, DNA Connexions, and Galaxy Labs all have different tests with different accuracy levels. Do your homework.
  • Next up, ease of use. You shouldn’t need a PhD to figure out how to use your kit. 
  • Then there’s speed. Some tests, like EIA and Western Blot deliver results quickly. Think about how quickly you want answers.
  • Customer support is another consideration. You want a company that’s got your back if you get stuck. Look for ones with hotlines or online help that’s actually helpful.
  • And finally, price. Lyme tests can cost a pretty penny. But don’t cheap out on your health. Find the best bang for your buck.


Conclusion The Best Lyme Disease Test Kit

In general, we recommend using a company that combines a combination of testing techniques to reduce the potential of false negatives. We feel that Vibrant Wellness does the most thorough job of combining technology as well as testing for the widest variety of microorganisms that can be transmitted with tick bites. While the most thorough version of their test requires a blood draw, they do offer the blood spot test (as mentioned), which requires only a finger stick of blood and can be done in the comfort of one’s home. This allows for the company to not only offer the most thorough testing on the market, but the ease of collection without going to a draw site. 

For more information on the topic of Lyme Disease Test Kit, see our other blog:

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