The Lyme disease test cost without insurance is $95 to $106 for a basic antibody blood test, based on Quest and IGeneX list prices as of November 8, 2026. Most specialty Lyme and co-infection tests at IGeneX list for $100 to $295 each, and culture-enhanced PCR lists for $730 to $960. If you are paying out of pocket and already feel unwell, the fear of buying the wrong test is real. The cheapest test is the right buy when it matches your timing and symptoms. My Lyme Doc helps patients in 11 states choose tests by video visit before they spend.
Updated November 2026: rebuilt with list prices read on each lab’s own website as of November 8, 2026.
Lyme disease test cost here means the lab’s published cash price for the test itself. Blood draw fees, the ordering clinician, and follow-up testing can add to it.
Lyme disease test prices in 2026 range from $95 for a basic antibody screen to $295 for a T-cell test, and $765 for IGeneX’s culture-enhanced Lyme PCR, by the labs’ own price lists. The table shows each list price as of November 8, 2026, and what that price leaves out. Our overview of each Lyme disease test explains the methods before you compare prices.
| Lab and test | What it looks for | List price (as of Nov 8, 2026) | Not included in that price |
|---|---|---|---|
| Quest consumer test 6646, Lyme Disease Test with Confirmation | Antibodies, using the CDC two-step process | $100 plus $6 service fee | In-home collection, if available, adds $99 |
| IGeneX 183, Lyme Serology IgG/IgM | Antibody screen | $95 | Blood draw fee and an ordering clinician |
| IGeneX 385 or 395, Lyme ImmunoBlot Speciation (IgM or IgG) | Antibodies, reported by Borrelia species | $100 each | Blood draw fee |
| IGeneX 601, Broad Coverage Lyme Ab Assay | An antibody assay IGeneX labels broad coverage | $195 | Blood draw fee |
| IGeneX 325 or 335, Lyme ImmunoBlot (IgM or IgG) | Antibody bands on an immunoblot | $225 each | Blood draw fee |
| IGeneX 450 to 456, Lyme Multiplex PCR | Borrelia DNA in urine, serum or whole blood | $265 | Blood draw fee for blood samples |
| IGeneX 300, Lyme IgXSpot | T-cell response to Borrelia | $295 | Blood draw fee |
| IGeneX 1100C, Lyme cePCR (culture enhanced) | Borrelia DNA after the sample is cultured | $765 | Blood draw fee |
Sources: Quest consumer test page and the IGeneX test directory, both read November 8, 2026. Labcorp’s consumer site showed a maintenance page that day, so its price is not listed. Prices change, so check the lab’s page on the day you order.
If you are still deciding between test types, our guide to the best Lyme disease test for your situation explains what each method measures.
Two-tier testing is the standard US approach: a first antibody screen, then a second confirming test if the screen is positive or unclear. A 2019 CDC recommendation accepts FDA-cleared formats that use a second immunoassay in place of the immunoblot.
Speciation blots report antibody results by Borrelia species. IgXSpot is the IGeneX T-cell test, which IGeneX describes as detecting T cells that react to Borrelia.
The cheapest Lyme antibody test by sticker price is the IGeneX Lyme Serology IgG/IgM at $95 as of November 8, 2026, but the Quest consumer test is often cheaper all in. The difference comes down to what each price includes.
Quest’s $106 total, as of November 8, 2026, covers the screen and, if it is positive, the confirmation test on the same sample. The Quest product page says that confirmation comes “at no extra cost to you.” After checkout, you schedule the blood draw at a Quest patient service center.
The IGeneX $95 list price, as of November 8, 2026, covers the screen only. An IGeneX immunoblot lists at $100 to $225 more on the same date, and the draw site charges a separate fee. IGeneX also takes a $20 test kit deposit, which it deducts from your test cost.
So for a first, standard two-tier test, Quest’s consumer test is usually the lower total. IGeneX costs more because it offers tests Quest’s consumer product does not, such as speciation blots, PCR and T-cell testing. Our IGeneX vs Quest comparison covers how the two labs differ beyond price.
A Lyme test’s list price usually covers the lab work only, so the bill you pay can be higher. Ask about each of these before you order.
On your call, Dr. Mueller reviews your symptoms, tick history and any past labs with you. Then she tells you which tests fit your case before you spend more.
Tick-borne disease panel costs depend on whether you buy single tests or one of IGeneX’s bundled panels. Here is what IGeneX listed for common Lyme co-infection tests as of November 8, 2026.
| IGeneX test | List price |
|---|---|
| Babesia microti or B. duncani IgM and IgG antibodies (IFA) | $160 each |
| Bartonella henselae IgM and IgG antibodies (IFA) | $160 |
| Ehrlichia (HME) or Anaplasma (HGA) antibodies (IFA) | $160 each |
| Babesia FISH or Bartonella FISH | $220 each |
| Babesia or Bartonella ImmunoBlot, IgM or IgG | $225 each |
| Babesia, Bartonella, Ehrlichia or Anaplasma PCR, whole blood | $230 each |
| Bartonella IgXSpot | $295 |
| Babesia or Bartonella cePCR (culture enhanced) | $730 each |
| Ehrlichia and Anaplasma cePCR (culture enhanced) | $960 |
IGeneX also sells bundled panels. These are a few of its listed panel prices as of November 8, 2026.
| IGeneX panel | List price |
|---|---|
| Lyme Multiplex PCR Panel 1 | $371 |
| Lyme ImmunoBlot Panel 1 | $490.50 |
| Tick Borne Disease Panel 7 | $495 |
| Co-Infection Panel 5 | $816 |
| TBD cePCR Test Panel | $1,499 |
| Tick Borne Disease Panel 11L, the highest listed | $3,517.50 |
Source for both tables: IGeneX test directory, read November 8, 2026. Ask which tests a panel includes before you compare it with single tests.
PCR looks for the organism’s genetic material. IFA and immunoblot tests look for your immune system’s antibodies against it.
Here is a worked example using those list prices. A Lyme ImmunoBlot IgM and IgG ($450), plus Babesia microti and Bartonella henselae antibody tests ($320), comes to $770 before the draw fee. Choosing tests by symptom pattern can cost less than ordering every test on the list. For how PCR fits a Lyme workup, see our guide to the PCR test for Lyme disease.
If night sweats or air hunger point toward Babesia, our Babesia testing guide explains which tests are used.
For Bartonella, our Bartonella testing guide explains which tests are used.
Our overview of co-infections testing covers Ehrlichia, Anaplasma and the rest.
Insurance coverage for Lyme disease testing depends on the lab and your plan, and the specialty labs often bill you directly. IGeneX is the clearest example.
The IGeneX FAQ says it “does not accept assignment from or submit claims to insurance companies” except for patients with Medicare Part B, and it also accepts most Medicare PPO plans. For other patients, IGeneX sends an itemized statement with the amount charged and the CPT procedure codes. You can submit that statement to your insurer, and IGeneX recommends calling your carrier first.
Medicare Part B covers medically necessary diagnostic lab tests when your provider orders them, and you usually pay nothing for a covered test, per Medicare.gov. Quest’s consumer Lyme test accepts HSA and FSA payment, according to its product page.
If you work with My Lyme Doc, lab fees are billed separately from the $300 initial video visit. Ask your plan about the lab charge on its own before the draw.
Test timing changes your results, which means it changes whether your money buys a useful answer. Antibody tests need your immune system to respond first.
A 2016 review by CDC scientists in Emerging Infectious Diseases found two-tier testing caught only 30% to 40% of early infections. Once infection had spread, sensitivity rose to 70% to 100%, and specificity stayed above 95%. The authors call the first few weeks the window period, when antibodies are still developing.
In plain terms, a test drawn too early can come back negative and leave you paying for a second one. If your result and your symptoms do not match, our guide on interpreting Lyme disease test results walks through what a negative can and cannot tell you.
You can lower what you pay for Lyme testing by comparing list prices and buying only the tests your case calls for. These steps help most.
For a wider look at the lab options, our list of lab tests for tick-borne diseases groups them by what they detect.
My Lyme Doc helps you decide which tests are worth paying for before you order them. The goal is fewer repeat tests and a clearer answer from the ones you buy.
Every new patient starts with a $300 initial video visit with Dr. Diane Mueller, collected at booking. On that call, she reviews your symptoms, tick and mold exposure history, and any labs you already have. Then she orders the tests your case calls for.
Lab fees are separate from the visit.
Testing feeds into Dr. Mueller’s 4-Phase Method, which builds the body first, then supports lifestyle and the nervous system, then gentle detox, then targeted microbe balancing. If you live in one of our 11 states, you can book your initial visit and bring your past results.
A basic Lyme antibody test lists at $95 to $106 without insurance, based on Quest and IGeneX prices as of November 8, 2026. Most specialty Lyme tests at IGeneX list for $100 to $295 each, and culture-enhanced Lyme PCR lists for $765, plus a draw fee.
As of November 8, 2026, IGeneX’s Lyme Serology IgG/IgM has the lowest sticker price at $95. Quest’s consumer test, at $100 plus a $6 fee, includes the confirmation test if the screen is positive, so it is often cheaper in total.
IGeneX sells PCR both as single tests, $230 to $295 each, or $730 to $960 for culture-enhanced PCR, and as panels, such as Lyme Multiplex PCR Panel 1 at $371 (list prices as of November 8, 2026). Ask which tests a panel includes before you compare it with single tests.
Quest’s consumer Lyme Disease Test with Confirmation listed at $100 plus a $6 service fee on November 8, 2026. In-home collection, where offered, adds $99.
A single standard test is in line with other self-pay labs. On Quest’s consumer site on November 8, 2026, its $100 price sat near the rheumatoid arthritis panel ($110) and ANA screen ($112). Costs climb with specialty and co-infection tests.
It depends on your lab and plan. IGeneX bills Medicare Part B and most Medicare PPO plans, and gives other patients an itemized statement with CPT codes to submit to their insurer.
Written and medically reviewed by Dr. Diane Mueller, ND, LAc, DAOM | Last reviewed: November 8, 2026
This article is for educational purposes and is not medical advice. It does not replace evaluation by a qualified clinician who knows your history. Work with your doctor before ordering tests or making any change to your care.
We have helped thousands of people in Colorado, Oregon, Wyoming, New Jersey, Pennsylvania, Texas, Wisconsin, New Hampshire, Alabama, South Dakota, and Vermont restore their health and quality of life by diagnosing and treating their Lyme Disease.
We have helped thousands of
people restore their health
and quality of life by diagnosing
and treating their Lyme Disease.
“Dr. Mueller’s approach to medicine is refreshing! There is only so much you can do with western medicine and in my life I was needing a new approach. By addressing the whole body, nutritional diet factors, environmental factors, blood work, and incorporating ideas I had not previously known, I was able to break through with my conditions. I am not only experiencing less pain in my life, but through the process of healing guided by Dr. Diane Mueller, I am now happy to say I have more consciousness surrounding how I eat, what to eat and when things are appropriate. Living by example Dr. Mueller has a vibrancy that makes you want to learn and know more about your body and overall health. I highly recommend her to anyone looking for new answers, a new approach to health, or in need of freedom from pain and limitations.”
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