The DNRS program is the Dynamic Neural Retraining System, an online brain retraining course that Annie Hopper created in 2008 and that costs $349.95 on its official site as of November 1, 2026. A PubMed search for the program’s full name that day returned no matching articles, so reported benefits rest on one observational study without a control group and company surveys.
If you have Lyme disease, mold illness, or a nervous system that reacts to everything, someone has probably told you to try brain retraining, and you deserve a straight read before you spend $349.95. Our guide to limbic system retraining explains the concept, and this page reviews one named program.
The DNRS program is a commercial brain retraining course that describes itself as a drug-free, self-directed neuroplasticity program for regulating the nervous system.
DNRS (Dynamic Neural Retraining System) is a branded course of daily mental exercises that aims to change how the brain’s threat-response circuits react to symptoms and triggers.
Neuroplasticity is the brain’s ability to change its connections in response to learning and repetition.
Annie Hopper developed DNRS in 2008, and her official page describes her as having recovered from disabling illnesses using her own brain-based program. That page lists no medical or academic degrees. A 2020 critique by David Tuller, DrPH, notes that she is not a doctor or a scientist.
The official program page says the course covers limbic system function, shifting unconscious trauma patterns, and targeted desensitization and visualization techniques. It also teaches what the company calls the Five Pillars of Recovery. The program is designed for adults 18 and older.
The company lists the conditions it serves, and the list includes chronic Lyme disease, mold illness, mast cell activation syndrome, multiple chemical sensitivity, POTS, fibromyalgia, chronic fatigue syndrome, Long COVID, anxiety, and PTSD. That list is the company’s own statement of scope and is not a research finding.
The base DNRS course, called DNRS 2.0, costs $349.95 USD on the official site as of November 1, 2026, and two bundles add coaching and community support.
| Option | Price (USD) | What is included |
|---|---|---|
| DNRS 2.0 | $349.95 | 13 hours of on-demand video, online manual, one year of streaming, basic forum access |
| Jump Start Bundle | $439.95 (listed at $519.00) | The video series plus one 60-minute individual coaching session |
| Support Bundle | $569.95 (listed at $799.95) | The video series, 12 weeks of group coaching, six months of laughter classes, six months of premium forum access |
After the first year, the site offers continued streaming for $20 a month. Its refund policy applies after six months of daily training if you received no value, and the refund carries a 15% processing fee. A return must start within 365 days of purchase.
The pages reviewed do not state how many minutes a day the training takes. Prices change, so confirm them on the official DNRS program page before you buy.
No controlled trial of the DNRS program has published results, and the evidence the company cites is one observational study from McMaster University.
An observational study follows people who chose a treatment and records how they do. It can show that scores changed, and it cannot show that the treatment caused the change.
Dr. Dale Guenter, a McMaster family doctor, presented the study at a Toronto primary care conference on November 17, 2019, according to David Tuller’s review. Of 150 people who attended DNRS workshops, 102 agreed to complete questionnaires. Respondents fell to 80 at three months, 70 at six months, and 64 at twelve months. Tuller reports that quality-of-life scores rose from baseline to three months with minimal change after that, and he argues the dropout may skew the averages. The company’s research page reports that the share of participants above the fibromyalgia cutoff fell from 76.9% to 26.7% over 12 months. The study had no comparison group, so neither result shows that DNRS caused the change.
| Source | Type | What it shows | Main limit |
|---|---|---|---|
| McMaster study, 2019 | Observational, 102 enrolled | Self-reported quality of life rose in the first 3 months | No control group, conference presentation, 64 responding at 12 months |
| Company 2025 survey | Participant survey | 95% report better emotional well-being, 94% better quality of life, 89% better physical health | Self-reported, and the home page states no sample size or comparison group |
| Khanpour Ardestani review, 2021 | Systematic review, ME/CFS | Listed DNRS as an eligible intervention, then included 12 studies of mindfulness, relaxation, qigong, yoga and similar approaches | DNRS was not among the included interventions, and the authors reported a high risk of bias |
| MILES trial, NCT06933173 | Randomized, wait-list control | Results not yet available | Recruiting since July 2025, in Long COVID and ME/CFS |
The MILES trial at the University of Alberta plans about 200 participants and compares DNRS with a wait-list group. It studies Long COVID and ME/CFS, so it will not answer the Lyme or mold question directly. The site’s own research page lists no randomized trial of DNRS.
On November 1, 2026, a PubMed search for DNRS in titles and abstracts alongside Lyme, mold, retraining or neuroplasticity returned three records, and none concerned the program. The reviewed sources contain no data on how many Lyme or mold patients improve with DNRS.
On a call, Dr. Mueller reviews your history and testing and explains where exposure, infection, and nervous system care belong in your plan before you buy a program.
Published criticism of DNRS centers on study design, the founder’s background, and the concern that brain retraining can displace medical evaluation.
Critics also grant points to the program. Tuller writes that components such as meditation or counseling may help some people, and he says whether to use DNRS is a personal call. Petrison acknowledges that some people find these programs useful for stress and community.
The company’s own site states that its content does not substitute for medical diagnosis, treatment, or advice, and it tells visitors to consult a health care provider first.
The DNRS program may suit a patient whose medical workup is complete, whose exposures are controlled, and who wants a structured, self-directed routine at a fixed cost.
My Lyme Doc’s published guides name DNRS as one example of structured brain retraining for patients who stay hypersensitive after the underlying biotoxin burden is addressed.
The mold brain fog guide describes adding limbic and vagal retraining, with programs such as DNRS or the Gupta Program as examples, once the biotoxin burden is down. It states that these are not a substitute for clearing the mold. The limbic system retraining guide adds that starting while severely inflamed, unstable, or in a major mold exposure may make the exercises feel like one more stressor.
Dr. Mueller’s 4-Phase Method builds the body first, then addresses lifestyle and the nervous system in Phase 02, which includes the Neuro Reset Program. Gentle detox and targeted microbe balancing follow. Dr. Ritchie Shoemaker’s CIRS framework, covered in our CIRS treatment protocol guide, is his own work.
Alternatives to the DNRS program include treating the underlying driver, therapist-led mind-body care with controlled trial data, and clinician-guided nervous system support.
Your decision comes down to six checks that take less time than the program itself.
My Lyme Doc sees patients by video visit in 11 states. If you want help placing nervous system work inside a full plan, you can book a call with Dr. Mueller.
Reported improvements come from a 2019 observational study and company surveys, and no controlled trial has published results. A randomized trial in Long COVID and ME/CFS is recruiting.
The base DNRS 2.0 course is $349.95 USD on the official site as of November 1, 2026, and the bundles run to $569.95. Streaming after year one is $20 a month.
The company lists both conditions. A PubMed search on November 1, 2026 found no study of the program in either.
It is an operating commercial program with published refund terms and a stated medical disclaimer. Whether it improves outcomes is the open question.
The official pages describe 12 to 13 hours of video, one year of access, and daily training. It does not state daily minutes on the pages reviewed.
Some patients do. Tell your clinician, and keep exposure and infection care going, because the program itself says it does not replace medical care.
Written and medically reviewed by Dr. Diane Mueller, ND, LAc, DAOM | Last reviewed: November 1, 2026
This article is for educational purposes and is not medical advice. It does not replace evaluation by a qualified clinician who knows your history. Work with your doctor before ordering tests or making any change to your care.
We have helped thousands of people in Colorado, Oregon, Wyoming, New Jersey, Pennsylvania, Texas, Wisconsin, New Hampshire, Alabama, South Dakota, and Vermont restore their health and quality of life by diagnosing and treating their Lyme Disease.
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